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Zorluk: OrtaSex Determination and Sex-Linked Traits

A woman with normal vision whose father was color-blind marries a man with normal vision. What is the probability that any male child born to this couple will be color-blind?

  1. A
    25%25\%
  2. 50%50\%Cevap
  3. C
    0%0\%
  4. D
    100%100\%

Cevap

The probability that any male child born to this couple will be color-blind is 50%50\%.
The mother is a carrier (XCXcX^C X^c) because she inherited the color-blindness allele (XcX^c) from her affected father. When crossed with a normal male (XCYX^C Y), sons inherit their Y chromosome from the father and one of the mother's two X chromosomes. Therefore, there is a 50%50\% chance that a son receives the XcX^c allele and manifests color blindness.

Adım Adım Çözüm

1
Determine the parental genotypes.
The woman's father was color-blind (XcYX^c Y), so she inherited the XcX^c allele. Being phenotypically normal, her genotype is XCXcX^C X^c (heterozygous carrier). The man has normal vision, so his genotype is XCYX^C Y.
Red-green color blindness is an X-linked recessive trait.
2
Construct a Punnett square for the cross XCXc×XCYX^C X^c \times X^C Y.
The possible offspring genotypes are XCXCX^C X^C (normal female), XCXcX^C X^c (carrier female), XCYX^C Y (normal male), and XcYX^c Y (color-blind male).
Each parent contributes one sex chromosome to offspring.
3
Calculate the probability specific to male offspring.
The male offspring genotypes are XCYX^C Y and XcYX^c Y. Out of these 22 possible male outcomes, 11 is color-blind (XcYX^c Y). The probability among male children is 12=50%\frac{1}{2} = 50\%.
The question asks specifically for the probability among sons, requiring evaluation within the male subset only.

Anahtar Kavram

Sex-Linked Inheritance and X-Linked Recessive Traits
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