A university medical center's bioethics review board evaluated three protocol proposals involving experimental treatments and data governance. Match each clinical research decision on the left with the governing normative principle on the right that most directly justifies that decision.
- An oncology team was permitted to administer an unapproved experimental cellular therapy to a terminally ill patient only after all approved therapeutic regimens had completely failed and the patient provided documented, informed consent.Investigational medical therapies may be ethically sanctioned if and only if conventional clinical alternatives have been exhausted and the recipient provides explicit, fully informed authorization.
- A clinical trial investigating an invasive pharmacological agent was barred from offering high cash stipends in economically depressed neighborhoods because the compensation could induce participants to disregard physical risks.Research subjects must not be offered financial remuneration substantial enough to undermine voluntary decision-making regarding substantial prospective bodily harms.
- A rare-disease research registry was required to redact all familial lineage markers from its open-access database, even though this omission partially reduced the analytical utility of the dataset for outside researchers.The obligation to protect individual and familial genetic privacy strictly supersedes maximizing the scientific utility of public research repositories.
Cevap
The experimental cellular therapy authorization matches the principle permitting unapproved interventions when standard options are exhausted and consent is documented; the prohibition on high trial stipends matches the principle forbidding financial inducements that impair voluntary risk assessment; and the lineage marker redaction mandate matches the principle prioritizing privacy over scientific data utility.
Each decision is governed by a distinct normative standard: permitting an experimental therapy when standard treatments fail and consent exists is justified by the rule establishing those precise criteria; restricting disproportionate stipends is justified by the principle protecting voluntary consent against financial distortion; and redacting database markers at the expense of analytical utility is justified by the principle establishing that privacy protections supersede database optimization.
Adım Adım Çözüm
Anahtar Kavram
Principle Identification and Application
Tahmini Süre:1m 30s