Match each characteristic clinical, serologic, or histologic finding with the most appropriate hepatobiliary disorder.
- Concentric, 'onion skin' periductal fibrosis involving both intrahepatic and extrahepatic bile ductsPrimary sclerosing cholangitis
- Granulomatous destruction of small intrahepatic interlobular bile ducts, highly associated with anti-mitochondrial antibodiesPrimary biliary cholangitis
- Prominent lymphoplasmacytic infiltrate with interface hepatitis, often accompanied by anti-smooth muscle antibodiesAutoimmune hepatitis
- Periodic acid-Schiff (PAS)-positive, diastase-resistant globular inclusion bodies within periportal hepatocytesAlpha-1 antitrypsin deficiency
- Extensive hemosiderin deposition within hepatocytes and Kupffer cells, strongly positive on Prussian blue stainHemochromatosis
Cevap
Properly match the unique histologic and serologic findings to the correct hepatic or biliary disease.
Each hepatobiliary condition has a classic histopathologic or serologic signature that is highly tested on exams. PBC is marked by AMA and intrahepatic granulomas. PSC is identified by periductal 'onion skin' fibrosis of intra- and extrahepatic ducts. Autoimmune hepatitis features plasma cells, interface hepatitis, and anti-smooth muscle antibodies. Alpha-1 antitrypsin deficiency is characterized by PAS-positive, diastase-resistant globules. Hemochromatosis is defined by hepatic iron overload, visualizable via Prussian blue staining.
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Anahtar Kavram
Diagnosis of hepatobiliary diseases based on specific histologic and serologic markers