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Zorluk: OrtaGastroenterology and Hepatology

An independent 7272-year-old male presents to the acute care clinic with a 66-hour history of severe, crampy left-sided abdominal pain and two episodes of bright red blood per rectum. Over the preceding three days, he experienced a viral gastroenteritis characterized by frequent watery stools and poor oral intake, which caused him to feel lightheaded upon standing. His past medical history includes heart failure with preserved ejection fraction, hypertension, and hyperlipidemia. His current medications are lisinopril, metoprolol, and atorvastatin.

Vital signs are heart rate 112/min112\text{/min}, blood pressure 105/65 mm Hg105/65\text{ mm Hg}, respiratory rate 18/min18\text{/min}, and oxygen saturation 96%96\% on room air. Physical examination shows dry mucous membranes and decreased skin turgor. The abdomen is soft but moderately tender to palpation in the left lower quadrant. There is no rebound tenderness, rigidity, or guarding. Bowel sounds are diminished.

Laboratory studies show:
Leukocyte count: 10,500/mm310,500\text{/mm}^3
Hemoglobin: 14.2 g/dL14.2\text{ g/dL}
Creatinine: 1.4 mg/dL1.4\text{ mg/dL} (baseline 0.9 mg/dL0.9\text{ mg/dL})
Lactic acid: 1.6 mmol/L1.6\text{ mmol/L} (normal: 0.5−2.2 mmol/L0.5-2.2\text{ mmol/L})

A CT scan of the abdomen with intravenous contrast reveals edema and thickening of the colonic wall isolated to the splenic flexure and descending colon. There is no evidence of pneumatosis intestinalis or free intraperitoneal air.

Which of the following is the most appropriate next step in management?

  1. Intravenous fluid resuscitation and bowel restCevap
  2. B
    Immediate exploratory laparotomy
  3. C
    Administration of intravenous meropenem
  4. D
    Administration of intravenous furosemide
  5. E
    Administration of intravenous sodium bicarbonate

Cevap

The correct approach is supportive management with intravenous fluid resuscitation and bowel rest.
The correct response provides the mainstay of treatment for nonocclusive ischemic colitis: supportive care. Ischemic colitis most commonly affects older adults following episodes of systemic hypotension or hypovolemia (e.g., severe diarrhea). The splenic flexure (Griffith point) and rectosigmoid junction (Sudeck point) are watershed areas highly vulnerable to decreased arterial flow. Because this patient lacks "red flag" surgical signs—such as peritonitis, hemodynamic collapse, lactic acidosis, or pneumatosis intestinalis on CT—the immediate goal is to restore colonic perfusion through intravenous fluid resuscitation and bowel rest.

Adım Adım Çözüm

1
Analyze the clinical presentation and history.
The patient has acute left-sided abdominal pain and hematochezia following a dehydrating illness, leading to hypovolemia (elevated creatinine, dry mucous membranes, tachycardia).
Identifying the low-flow state is critical to determining the etiology of the intestinal ischemia.
2
Interpret the diagnostic imaging.
CT shows wall thickening at the splenic flexure without pneumatosis or free air.
This confirms nonocclusive ischemic colitis at a watershed area and rules out perforation or transmural gangrene.
3
Determine the appropriate intervention.
Select supportive medical management to restore perfusion.
Because the ischemia is nonocclusive and there are no signs of peritonitis, surgical and aggressive antibiotic therapies are deferred in favor of restoring circulating volume.

Anahtar Kavram

Management of nonocclusive ischemic colitis focuses on supportive care, including intravenous fluid resuscitation, to restore colonic perfusion in patients without signs of peritonitis or bowel necrosis.
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