A -year-old woman comes to the office due to the absence of menstrual periods for the past months. Previously, she had regular -day cycles with normal bleeding. Over the same -month period, she has noticed worsening acne, increased thick hair growth on her face and abdomen, and a deepening of her voice. She has no significant past medical history and takes no medications. A urine pregnancy test obtained in the clinic is negative. Vital signs are temperature , blood pressure , pulse , and respirations . BMI is . Physical examination reveals temporal hair thinning and terminal hair on the upper lip, chin, and linea alba. Pelvic examination shows clitoromegaly and a normal-sized, mobile uterus. Adnexae are difficult to palpate. Which of the following is the most appropriate next step in management?
- Measurement of serum testosterone and dehydroepiandrosterone sulfateCevap
- BPrescription of combined oral contraceptives
- CMeasurement of serum thyroid-stimulating hormone and prolactin
- DEndometrial biopsy
- EReassurance and clinical observation