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Zorluk: ZorGastroenterology and Hepatology

A 4747-year-old man with a history of ulcerative colitis, chronic obstructive pulmonary disease (COPD), and hypothyroidism is evaluated in the intensive care unit. He was admitted 22 days ago for a severe ulcerative colitis flare characterized by >10>10 bloody bowel movements per day and was started on intravenous methylprednisolone. Over the past 1212 hours, his diarrhea has abruptly ceased, but he has developed severe, diffuse abdominal pain and progressive distension.

Vital signs:
- Temperature: 39.3∘C39.3^\circ\text{C} (102.7∘F102.7^\circ\text{F})
- Blood pressure: 84/52 mm Hg84/52 \text{ mm Hg}
- Heart rate: 136/min136/\text{min}
- Respiratory rate: 28/min28/\text{min}

Physical examination reveals a markedly distended abdomen with diffuse rebound tenderness and rigidity. Bowel sounds are absent. Lung auscultation reveals faint, scattered expiratory wheezes bilaterally.

Laboratory studies:
- Leukocytes: 25,500/mm325,500/\text{mm}^3
- Bicarbonate: 13 mEq/L13 \text{ mEq/L}
- Arterial blood gas (on room air): pH 7.247.24, PaCO2PaCO_2 30 mm Hg30 \text{ mm Hg}, PaO2PaO_2 68 mm Hg68 \text{ mm Hg}
- TSH: 0.1μU/mL0.1 \mu\text{U/mL} (Normal: 0.40.4-4.04.0)
- Free T4: 0.5 ng/dL0.5 \text{ ng/dL} (Normal: 0.90.9-1.71.7)
- Lactic acid: 7.2 mmol/L7.2 \text{ mmol/L} (Normal: 0.50.5-2.22.2)

An upright abdominal radiograph shows a continuous column of gas in the transverse colon measuring 8.5 cm8.5 \text{ cm} in diameter with a loss of normal haustral markings. No free air under the diaphragm is visualized.

Which of the following is the most appropriate next step in the management of this patient?

  1. Emergency subtotal colectomyCevap
  2. B
    Insertion of a nasogastric tube and serial abdominal examinations
  3. C
    Intravenous sodium bicarbonate infusion
  4. D
    Intravenous levothyroxine administration
  5. E
    Intravenous furosemide administration

Cevap

Emergency subtotal colectomy
This patient presents with toxic megacolon, a life-threatening complication of severe ulcerative colitis. The diagnosis is confirmed by radiographic evidence of colonic dilation (>6 cm>6 \text{ cm}) combined with systemic toxicity (fever, tachycardia, prominent leukocytosis, and hypotension). While the initial management of toxic megacolon consists of medical therapy (intravenous fluids, broad-spectrum antibiotics, and high-dose corticosteroids), the development of peritonitis (rebound tenderness and abdominal rigidity) or worsening shock indicates full-thickness bowel ischemia or micro-perforation. In this clinical scenario, emergency surgical intervention—typically a subtotal colectomy with an end ileostomy—is the definitive and life-saving next step.

Adım Adım Çözüm

1
Diagnose the primary condition based on clinical presentation and imaging.
The patient has toxic megacolon, evidenced by colonic dilation >6 cm>6 \text{ cm}, fever, tachycardia, leukocytosis, and shock, occurring in the setting of a severe ulcerative colitis flare.
Applying Jalan's diagnostic criteria for toxic megacolon is necessary to guide severity assessment and subsequent management.
2
Assess for complications indicating failure of medical management.
The new onset of diffuse rebound tenderness and rigidity indicates peritonitis, likely from full-thickness colonic ischemia or impending perforation.
Identifying peritonitis shifts the treatment paradigm from medical resuscitation to urgent surgical source control.
3
Select the appropriate definitive intervention.
Emergency subtotal colectomy with end ileostomy is required immediately.
While toxic megacolon is initially managed with intravenous corticosteroids and antibiotics, peritonitis or hemodynamic collapse mandates surgical resection to save the patient's life.

Anahtar Kavram

Toxic megacolon complicated by peritonitis or refractory shock requires emergency surgical intervention, typically a subtotal colectomy.
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