A 39-year-old woman, G0, comes to the clinic due to a three-week history of continuous, heavy vaginal bleeding. She states that she has soaked through a thick maxi pad every 3 hours for the past week. The patient has a history of irregular menstrual cycles, with periods occurring unpredictably every 2 to 6 months since menarche. Medical history is notable for hypertension, for which she takes amlodipine. She does not use tobacco or alcohol. Her blood pressure is , pulse is , and BMI is . Physical examination reveals dark, velvety patches of skin on the posterior neck and axillae. Pelvic examination shows active bleeding from the cervical os; the uterus is normal in size and non-tender. A urine pregnancy test is negative. Complete blood count shows a hemoglobin of and a platelet count of . Thyroid-stimulating hormone level is within normal limits. Which of the following is the most appropriate next step in management?
- ATransvaginal ultrasonography
- BMeasurement of serum 17-hydroxyprogesterone
- Endometrial biopsyCevap
- DInitiation of oral medroxyprogesterone acetate
- EMeasurement of serum free thyroxine