A 29-year-old female patient is evaluated in the surgical intensive care unit on postoperative day two following an uncomplicated open cholecystectomy. Over the past four hours, she has become profoundly delirious and agitated. Her husband notes she has a history of "mild hyperthyroidism" for which she had been taking medication intermittently, but she completely discontinued all medical therapy one month ago.
Vital signs demonstrate a temperature of (), pulse of , blood pressure of , and respirations of .
Physical examination reveals an actively hallucinating and diaphoretic patient. Ophthalmic examination shows bilateral proptosis and lid retraction. The thyroid gland is diffusely enlarged, firm, and a continuous bruit is audible over the lateral lobes. Cardiovascular examination reveals a regular, rapid rhythm with a hyperdynamic precordium. A fine tremor is present in the upper extremities. Laboratory studies reveal a TSH of and free T4 of .
Arrange the following pharmacologic interventions in the strictly correct chronological sequence to maximize therapeutic efficacy and prevent an acute exacerbation of this patient's underlying condition.
- 1Administration of intravenous propranolol
- 2Administration of oral propylthiouracil
- 3Administration of saturated solution of potassium iodide
- 4Administration of oral cholestyramine