A -year-old woman is brought to the emergency department by her husband due to severe agitation, confusion, and a pounding heartbeat. She has a history of Graves disease but reports discontinuing all her medications four months ago because she felt well. Two days ago, she developed a severe sore throat, cough, and subjective fever.
Vital signs are temperature (), blood pressure , pulse and irregularly irregular, and respirations .
On physical examination, the patient is delirious, profusely diaphoretic, and uncooperative. She has prominent proptosis and a diffusely enlarged, non-tender thyroid gland with an audible bruit. Neuromuscular examination reveals marked hyperreflexia and a fine resting tremor. An electrocardiogram confirms atrial fibrillation with a rapid ventricular response.
Following initial airway stabilization and intravenous fluid resuscitation, arrange the following pharmacologic interventions in the required chronological sequence for the definitive management of this patient's endocrine emergency.
- 1Intravenous propranolol
- 2Oral propylthiouracil
- 3Oral potassium iodide