Soru

A 34-year-old woman is evaluated in the gastroenterology outpatient clinic for a 6-month history of chronic, non-bloody, voluminous diarrhea and a 4-kg (8.8-lb) weight loss. She also reports severe, generalized fatigue. On physical examination, her vital signs are within normal limits. Skin examination reveals an intensely pruritic, papulovesicular eruption symmetrically distributed over her extensor surfaces, particularly the elbows, knees, and buttocks. Laboratory studies demonstrate a microcytic anemia with a remarkably low serum ferritin level. The physician strongly suspects an underlying immune-mediated gastrointestinal disorder and performs an esophagogastroduodenoscopy with multiple biopsies from the distal duodenum. Which of the following histopathologic findings are characteristic of this patient's underlying condition and would most likely be observed on the biopsy specimen? (Select all that apply)